Molecular Mimicry – BCMG Resolution Project

As I posted about a few months ago, earlier this year I was involved in BCMG’s Resolution project, exploring scientific research through music and I composed a piece for secondary school students to perform. As part of my research, I drew a little storyboard which was made into a little film (thanks to Jonathan Lee). I’ve finally managed to put the audio recording of the performance by the students together with the animation. And here it is (make sure you turn your sound up – the beginning is very quiet):

Programme note:

Molecular mimicry’ is a term that describes the process of the body’s immune system mis-recognising its own antigens (particular proteins which live on the surface of cells) for those of a foreign pathogen and attacking itself. This piece explores the hypothesized process of the body developing Sjögrens syndrome.

Firstly the musical form of an oral bacterium called Porphyromonas gingivalis (P. Gingivalis) is heard:

Molecular Mimicry Melody

This bacteria, or pathogen, is very similar in appearance to some of the body’s own cells. In the music this is represented rhythmically similar harmonies. The melody and harmonies are locked into by another rhythm:

Molecular Mimicry Counter-melody

This depicts the way the body uses a ‘lock and key’ type mechanism when discovering and reacting to particular antigens. See https://www.youtube.com/watch?v=QIN5sSUlZWk

This in turn triggers an immune response – an alarm – and the body begins to attack itself. In Sjögrens Syndrome this takes a number of forms, one of which is that the tear ducts and mouth dry up, shown in the music by the change from loud resonant sounds into high pitched dry, scratchy sounds.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s