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Birmingham Community Music Jeremy Clay New Music The Arts Workshops

Molecular Mimicry – BCMG Resolution Project

As I posted about a few months ago, earlier this year I was involved in BCMG’s Resolution project, exploring scientific research through music and I composed a piece for secondary school students to perform. As part of my research, I drew a little storyboard which was made into a little film (thanks to Jonathan Lee). I’ve finally managed to put the audio recording of the performance by the students together with the animation. And here it is (make sure you turn your sound up – the beginning is very quiet):

Programme note:

Molecular mimicry’ is a term that describes the process of the body’s immune system mis-recognising its own antigens (particular proteins which live on the surface of cells) for those of a foreign pathogen and attacking itself. This piece explores the hypothesized process of the body developing Sjögrens syndrome.

Firstly the musical form of an oral bacterium called Porphyromonas gingivalis (P. Gingivalis) is heard:

Molecular Mimicry Melody

This bacteria, or pathogen, is very similar in appearance to some of the body’s own cells. In the music this is represented rhythmically similar harmonies. The melody and harmonies are locked into by another rhythm:

Molecular Mimicry Counter-melody

This depicts the way the body uses a ‘lock and key’ type mechanism when discovering and reacting to particular antigens. See https://www.youtube.com/watch?v=QIN5sSUlZWk

This in turn triggers an immune response – an alarm – and the body begins to attack itself. In Sjögrens Syndrome this takes a number of forms, one of which is that the tear ducts and mouth dry up, shown in the music by the change from loud resonant sounds into high pitched dry, scratchy sounds.

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Birmingham Community Music Jeremy Clay New Music Teaching The Arts Workshops

A River Through History – CBSO Performance

A River Through History Title Page

Yesterday I attended both of the CBSO’s schools concerts involving the final performance for the Birmingham History Project I have been involved with. The full orchestra performed in Symphony Hall with audiences of 2000 children in each concert.

The reason for my excitement was that I had arranged a piece written by secondary school pupils from Shenley Academy for the full orchestra to perform. Earlier in May the young people performed the piece themselves at the CBSO Centre, then I went away and arranged it for the orchestra. My main concern whilst arranging the music was that I needed to balance needing to make the piece sound ‘orchestral’ and giving it a ‘professional’ edge, without losing the sense of the original material composed by the young people.

The ideas from the students were really good and fortunately I was able to work really well with the material they had composed without adding to it very much at all. I felt like I was able to be true to their original intentions. Fortunately I was able to go into the school and do a session with them to explain to them exactly what I had done with their piece, so that they could understand why they might not hear ‘their bit’ played by the same instrument or in the same way. I think this was a really valuable session.

From talking to them after the concert, they seemed really pleased that they could hear ‘their music’ in the piece even though I hadn’t just taken their piece note by note and orchestrated it.

It has taken a lot of work, but I’m really pleased with the way it turned out. I’m hoping to get a recording online soon.

A River Through History - Page 1

A River Through History double pageA River Through History section